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Article in Japanese
Abstract
Case Report
A case of a thoracic SMARCA4-deficient undifferentiated tumor which was difficult to distinguish from small cell lung cancer
Shohei Mizobuchia Jun Sakakibara-Konishia Nana Munakataa Kenjiro Katob Noriyuki Otsukab Satoshi Konnoa
aDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University
bDepartment of Surgical Pathology, Hokkaido University Hospital
ABSTRACT
A 61-year-old man was referred to our hospital with a complaint of bloody sputum and dyspnea. A large mass was found in the lower lobe of the right lung and the mediastinum. Neuron-specific enolase (NSE) and pro-gastrin-releasing peptide (ProGRP) levels were elevated. Based on the results of the mediastinal lymph node biopsy, small cell lung cancer, poorly differentiated carcinoma, and sarcoma were suspected. Although chemotherapy was initiated for small cell lung cancer, the tumor grew rapidly and the patient died on the 25th day after the initiation of chemotherapy. Postmortem immunostaining and pathological autopsy revealed a thoracic SMARCA4-deficient undifferentiated tumor. In scenarios involving large hilar or mediastinal masses, it is prudent to include SMARCA4-deficient undifferentiated tumors as a differential diagnosis.
KEYWORDS
Thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT)
Received 27 Feb 2024 ／ Accepted 1 May 2024
AJRS, 13(4): 189-192, 2024
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