Annals of The Japanese Respiratory Society:A case of a very elderly man with <i>MET</i> mutation-positive advanced non-small cell lung cancer successfully treated with tepotinib

Abstract

Article in Japanese

Case Report

A case of a very elderly man with MET mutation-positive advanced non-small cell lung cancer successfully treated with tepotinib

Shunichi Nomura^a Kazuyoshi Watanabe^a Akihito Bando^a Yuki Seike^a Tamami Sakai^a Seiji Yano^b

^aDepartment of Respiratory Medicine, Japan Community Health Care Organization Kanazawa Hospital
^bDepartment of Respiratory Medicine, Kanazawa University Hospital

ABSTRACT

The patient, a 90-year-old man, was diagnosed with right upper lobe lung adenocarcinoma (cT4N3M0, clinical stage IIIC, Oncomine^TM Dx Target Test Multi-CDx system: MET exon14 skipping positive, ArcherMET ex14 skipping positive) and started systemic chemotherapy with tepotinib as first-line treatment. The tumor had begun to shrink within a week which was judged to be a partial response. The patient showed Grade 2 creatinine increase and Grade 1 edema during the treatment. This was a case in which the efficacy of tepotinib in a very elderly patient was confirmed.

KEYWORDS

Non-small cell lung cancer MET exon 14 skipping mutation MET inhibitor Tepotinib

Received 17 Nov 2023 ／ Accepted 5 Jan 2024

AJRS, 13(2): 54-58, 2024

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Abstract

Case Report

ABSTRACT

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