Annals of The Japanese Respiratory Society:Anti-TIF1-γ antibody-positive dermatomyositis as a tumor-associated syndrome due to worsening lung cancer

Vol.12 No.5 Table of Contents

Abstract

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Article in Japanese

Case Report

Anti-TIF1-γ antibody-positive dermatomyositis as a tumor-associated syndrome due to worsening lung cancer

Kiyohide Komuta^a Satoshi Tanaka^a Junji Uchida^a Hiroaki Fushimi^b Kiyonobu Ueno^a

^aDepartment of Respiratory Medicine, Osaka General Medical Center
^bDepartment of Pathology, Osaka General Medical Center

ABSTRACT

A 75-year-old woman was diagnosed with lung adenocarcinoma Stage IVA [cT2aN3M1a (PLE)] with EGFR L861Q mutation. She was treated with osimertinib without any significant adverse events. However, 2 years later, she developed anti-TIF1-γ antibody-positive dermatomyositis. Because of a simultaneous recurrence of lung cancer, we considered dermatomyositis to be a paraneoplastic syndrome associated with the worsening of cancer. During the administration of anticancer therapy, the dermatomyositis symptoms persisted. They improved with low doses of steroids. In the diagnosis and treatment of rare conditions, it is important to improve the quality of medical care through close collaboration with other departments.

KEYWORDS

Lung adenocarcinoma Anti-transcriptional intermediary factor 1-gamma (TIF1-γ) antibody Dermatomyositis Paraneoplastic syndrome

Received 27 Mar 2023 ／ Accepted 29 May 2023

AJRS, 12(5): 261-264, 2023

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