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Abstract

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Article in Japanese

Case Report

An autopsy case report of diffuse large B-cell lymphoma with diffuse ground-glass opacity

Soichi Iwanaka  Tadashi Nishimura  Hirotoshi Tarumi  Chikashi Tsuji  Yasumasa Sakakura  Masahiro Naito 

Department of Pulmonary Medicine, Mie Chuo Medical Center

ABSTRACT

A 78-year-old man was referred to our hospital for fever and fatigue. Chest computed tomography (CT) scan revealed ground-glass opacity, predominantly in both upper lobes, and a mass shadow in the left lower lobe. He was given a tentative diagnosis of infection but although he received antibiotics, his fever did not improve. We performed a transbronchial lung biopsy; however, we did not obtain meaningful diagnostic findings. On his ninth day in the hospital, he was administered methylprednisolone pulse therapy because of respiratory failure and his condition improved. A CT scan was performed again on the 21st day of admission and showed para-aortic lymph node enlargement, a left adrenal grand mass, and increased retroperitoneal fatty tissue density. To obtain a definitive diagnosis, we performed CT-guided needle biopsy on the mass shadow in the left lower lobe. The histopathological findings revealed diffuse large B-cell lymphoma. The patient was therefore scheduled to be transferred to a hospital specializing in hematological diseases, but he died on the 30th day of admission. An autopsy revealed that the malignant lymphoma had infiltrated multiple organs. In cases of abnormal lung findings refractory to antibiotics, it is important to consider malignant lymphoma as a differential diagnosis.

KEYWORDS

Diffuse large B-cell lymphoma (DLBCL)  Ground-glass opacity (GGO) 

Received 23 Aug 2022 / Accepted 12 Jan 2023

AJRS, 12(3): 134-137, 2023

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