一般社団法人日本呼吸器学会 公式サイト
日本呼吸器学会英文誌 Respiratory Investigation
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集

Abstract

Full Text of PDF Full Text of PDF (369k)  required ID / password
Article in Japanese

Case Report

A case of coronavirus disease 2019 needs to be differentiated from pulmonary complications of graft versus host disease

Ryosuke Morioa  Takahiro Takazonoa,b  Nobuyuki Ashizawaa,c  Kazuko Yamamotoa  Koichi Izumikawab,c  Hiroshi Mukaea 

aDepartment of Respiratory Medicine, Nagasaki University Hospital
bDepartment of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences
cInfection Control and Education Center, Nagasaki University Hospital

ABSTRACT

A 64-year-old man who had undergone an allogeneic hematopoietic stem cell transplantation due to acute myeloid leukemia presented with dyspnea lasting for 18 days. Chest computed tomography showed bilateral patchy consolidations and ground-glass opacities. At first, we suspected pulmonary complications of graft versus host disease (GVHD), as he had been diagnosed with chronic gastrointestinal and dermal GVHD. SARS-CoV-2 antigen and polymerase chain reaction tests showed negative results. However, serologic antibody testing of SARS-CoV-2 nucleocapsid (N) protein proved positive, and we clinically diagnosed coronavirus disease 2019 (COVID-19). In cases with COVID-19 symptoms which last for over 2 weeks, SARS-CoV-2 N antibody tests can be useful. In this COVID-19 era, we should consider COIVD-19 as one of the differential diagnoses when a patient shows interstitial shadows, even if the SARS-CoV-2 PCR test is negative.

KEYWORDS

Allogeneic hematopoietic stem cell transplantation  Graft versus host disease (GVHD)  Coronavirus disease 2019 (COVID-19)  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)  SARS-CoV-2 N antibody test 

Received 31 Jan 2022 / Accepted 6 Jun 2022

AJRS, 11(5): 296-300, 2022

Google Scholar