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日本呼吸器学会英文誌 Respiratory Investigation
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Abstract

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Article in Japanese

Case Report

A case of primary pulmonary malignant melanoma treated with nivolumab plus ipilimumab

Shinji Kakumotoa  Yusuke Takayamaa  Yasuo Iwamotob  Ren Seikea  Shohei Mishimaa  Hiroyasu Shodaa 

aDepartment of Respiratory Medicine, Hiroshima City Hiroshima Citizens Hospital
bDepartment of Oncology, Hiroshima City Hiroshima Citizens Hospital

ABSTRACT

A 69-year-old woman presented to our hospital with productive cough. Contrast-enhanced chest computed tomography showed a mass occupying the right lower lobe. Bronchoscopy showed a brown-colored mass obstructing the right lower lobe bronchus and the pathological findings revealed malignant melanoma. Further evaluation and immunohistochemical examination provided the definitive diagnosis of primary pulmonary malignant melanoma with metastasis to the mediastinal lymph nodes, muscles, and bones. She received four courses of combination chemotherapy with nivolumab and ipilimumab, followed by three cycles of maintenance chemotherapy with nivolumab. Despite the use of chemotherapy, the tumor increased in size, and she died of a urinary tract infection six months after diagnosis. Primary pulmonary malignant melanoma is a very rare disease and there is no established treatment. Here, we describe a case of primary pulmonary malignant melanoma treated with nivolumab plus ipilimumab.

KEYWORDS

Primary pulmonary malignant melanoma  Nivolumab  Ipilimumab  Immune checkpoint inhibitor (ICI) 

Received 27 Aug 2021 / Accepted 12 Jan 2022

AJRS, 11(2): 98-102, 2022

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