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Abstract

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Article in Japanese

Case Report

Tuberous sclerosis complex associated with bulla expansion during follow-up for multifocal micronodular pneumocyte hyperplasia: a case report

Yukari Shimizu  Hiroya Kawaguchi  Hirotaka Maruyama  Hiromi Yamane  Makoto Ando  Kiyotaka Ito 

Department of Respiratory Medicine, Kumamoto Rosai Hospital

ABSTRACT

We report the case of a 31-year-old woman in whom chest radiography and computed tomography revealed nodular shadows and a right inferior lung lobe cyst. Histopathological evaluation of a biopsy specimen confirmed that the nodular shadows represented multifocal micronodular pneumocyte hyperplasia (MMPH), and the patient was diagnosed with tuberous sclerosis complex. We monitored the cyst, which showed gradual expansion. We therefore resected the bulla, and histopathological evaluation showed MMPH in the alveolar wall at the proximal aspect of the bulla. In our opinion, the check-valve mechanism associated with MMPH contributed to cyst formation and growth. We present a rare case of MMPH that resulted in a cystic lesion.

KEYWORDS

Tuberous sclerosis complex (TSC)  Multifocal micronodular pneumocyte hyperplasia (MMPH)  Check-valve mechanism 

Received 14 Jun 2021 / Accepted 23 Aug 2021

AJRS, 10(6): 499-502, 2021

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