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Abstract

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Article in Japanese

Case Report

A case of small cell lung cancer with anterior hypopituitarism and diabetes insipidus due to pituitary metastasis treated with multimodal therapy

Takahiro Shimizua  Johsuke Haraa  Kyouta Akasakia  Yujiro Nakanob  Hideharu Kimuraa  Kazuo Kasaharaa 

aDepartment of Respiratory Medicine, Kanazawa University Hospital
bDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences

ABSTRACT

A 76-year-old male patient was diagnosed with limited disease small cell lung cancer, cT1aN2M0 Stage IIIA. He was treated with concurrent chemotherapy and chest radiotherapy. After three courses of chemotherapy, he complained of nausea and anorexia and was admitted to our hospital. Laboratory examination showed decreased anterior pituitary function. He was diagnosed with anterior hypopituitarism due to pituitary metastasis. After the initiation of glucocorticosteroid replacement therapy, his anorexia and nausea improved. He was also diagnosed with diabetes insipidus. Endocrine function did not improve after whole-brain irradiation for pituitary metastasis, but the nausea and anorexia improved with hormone replacement therapy.

KEYWORDS

Pituitary metastasis  Anterior hypopituitarism  Small cell lung cancer 

Received 1 Jun 2021 / Accepted 24 Aug 2021

AJRS, 10(6): 457-462, 2021

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