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Abstract

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Article in Japanese

Case Report

A case of high-grade lung mucoepidermoid carcinoma on hemodialysis successfully treated with pembrolizumab

Mitsuyoshi Utsugi  Shou Ohsawa  Akihiro Ono 

Department of Internal Medicine, Kiryu Kosei General Hospital

ABSTRACT

A 59-year-old man on hemodialysis was referred to our hospital with cough and chest pain, and a left upper lobe mass was detected on chest CT. He was diagnosed with Stage IVB high-grade lung mucoepidermoid carcinoma. PD-L1 evaluation was performed by immunohistochemistry and the PD-L1 tumor proportion score was more than 75%. Therefore, he received pembrolizumab as a first-line treatment, resulting in a partial response. He received a total of 22 courses of treatment, which were discontinued due to the onset of atrial fibrillation. He maintained a partial response for about 6 months after the cessation of treatment with pembrolizumab. Lung mucoepidermoid carcinoma is rare, and effective treatment has not yet been established for advanced-stage cases. This case suggests that pembrolizumab could be effective for the treatment of lung mucoepidermoid carcinoma with high PD-L1 expression.

KEYWORDS

Lung mucoepidermoid carcinoma  Hemodialysis  Anti PD-1 antibody  Pembrolizumab 

Received 26 Mar 2021 / Accepted 2 Jul 2021

AJRS, 10(5): 407-410, 2021

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