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Abstract

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Article in Japanese

Case Report

A case of hepatitis B virus reactivation during treatment with osimertinib

Meiko Morita  Yoshiyuki Oyama  Shogo Nakamura  Rie Mori  Masaki Ikeda  Hideki Kusagaya 

Department of Respiratory Medicine, Shizuoka Saiseikai General Hospital

ABSTRACT

A 79-year-old woman was diagnosed with advanced lung adenocarcinoma harboring an epidermal growth factor receptor (EGFR) exon 19 deletion. At the same time, she was diagnosed as an inactive hepatitis B virus (HBV) carrier. After consultation with a gastroenterologist, we initiated osimertinib treatment without antiviral prophylaxis. After 8 months, she developed general malaise and was admitted to our hospital because of liver dysfunction. Her hepatitis B surface antigen and HBV-DNA levels were higher than those before treatment; therefore, she was diagnosed with HBV reactivation. Her condition improved with entecavir. HBV reactivation caused by EGFR-tyrosine kinase inhibitor is rare; however, a cautious clinical follow-up is necessary.

KEYWORDS

Lung cancer  Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)  Osimertinib  Hepatitis B virus (HBV) reactivation 

Received 25 Mar 2021 / Accepted 14 Jun 2021

AJRS, 10(5): 388-392, 2021

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