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Abstract

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Article in Japanese

Case Report

A case of anti-MDA5 antibody-positive interstitial lung disease complicated by immune thrombocytopenia that followed an aggressive course

Juri Kawasaki  Toshikazu Takasaki  Masashi Bando  Naoko Mato  Takuji Suzuki  Koichi Hagiwara 

Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University

ABSTRACT

A 63-year-old man was transferred to our hospital with fever, cough, and dyspnea. Three months prior to admission, he had developed edema of both upper eyelids. On admission, in addition to typical cutaneous lesions, chest computed tomography showed diffuse ground glass attenuation and consolidation of bilateral lungs. He was diagnosed with rapidly progressive interstitial lung disease complicated by dermatomyositis. Despite immediate immunosuppressive therapy, he died on day 5 due to respiratory failure. The anti-MDA5 antibody had increased to 4,650 index. He was diagnosed with immune thrombocytopenia (ITP) because of severe thrombocytopenia 5×103/μL on admission, bone marrow aspiration, and elevated platelet-associated immunoglobulin G. Anti-MDA5 antibody-positive interstitial lung disease may be accompanied by ITP. We should consider ITP as a comorbidity when we encounter cases with anti-MDA5 antibody-positive interstitial lung disease accompanied by thrombocytopenia.

KEYWORDS

Anti-melanoma differentiation-associated gene 5 (MDA5) antibody  Dermatomyositis (DM)  Rapidly progressive interstitial lung disease (RP-ILD)  Immune thrombocytopenia (ITP)  Hemophagocytic syndrome (HPS) 

Received 3 Oct 2020 / Accepted 2 Feb 2021

AJRS, 10(3): 288-292, 2021

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