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Abstract

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Article in Japanese

Case Report

A case of lung adenocarcinoma harboring EGFR L858R/ex 19 del/T790M mutations

Hideto Oshita  Tatsuki Takahashi  Misato Senoo  Kunihiko Funaishi  Yasuyuki Mitama  Ken Okusaki 

Department of Internal Medicine, Mihara Medical Association Hospital
*Present address: Department of Respiratory Internal Medicine, Yoshijima Hospital

ABSTRACT

A 68-year-old woman had been treated for EGFR exon 21 L858R mutation-positive lung adenocarcinoma of the right upper lobe for two years. A new consolidation appeared in the left lower lobe, and adenocarcinoma was detected by transbronchial lung biopsy. In addition to the known L858R mutation, exon 19 deletion and T790M mutation were detected by EGFR mutation analysis. Although CT scan showed a temporary reduction of the consolidation in the left lower lobe after the start of osimertinib administration, disease progression was observed within a short period of time. We report a rare case of lung cancer in which the EGFR T790M mutation was added to compound common mutations of EGFR.

KEYWORDS

EGFR-mutant lung adenocarcinoma  Compound mutation  EGFR tyrosine kinase inhibitor (EGFR-TKI) 

Received 17 Dec 2020 / Accepted 8 Feb 2021

AJRS, 10(3): 264-267, 2021

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