一般社団法人日本呼吸器学会 公式サイト
日本呼吸器学会英文誌 Respiratory Investigation
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集 検索用
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集 全文PDF

Abstract

Full Text of PDF Full Text of PDF (503k)
Article in Japanese

Case Report

A case of bronchial anthracofibrosis associated with silicate inhalation

Yuki Hoshino  Sou Shimamura  Shuichirou Ide  Kazuki Masuda  Hiroshi Ishihara 

Department of Internal Medicine II, Faculty of Medicine, University of Yamanashi

ABSTRACT

Bronchial anthracofibrosis is defined as bronchial pigmentation with stenosis/obstruction observed on bronchoscopy, but its pathology remains unclear. An 86-year-old retired stonemason presented with recent onset of breathlessness. Computed tomography (CT) scan showed bilateral hilar and mediastinal lymphadenopathy and bronchial obstruction of right B3, but typical signs of silicosis were absent. Bronchoscopy revealed anthracosis on several parts of the bronchial epithelium including that on the obstructed right B3. In spite of the extensive uptake of 18F-FDG to the enlarged lymph nodes, repeated bronchoscopy could not demonstrate any sign of tuberculosis or malignancy, and a diagnosis of bronchial anthracofibrosis was made. After he died of recurrent idiopathic thrombocytopenic purpura, his right lung was examined. In the hilar lymph nodes, numerous dust-laden macrophages and other inflammatory cells were aggregated and these cells were distributed continuously to the swollen bronchial epithelium. Electron microscopical analysis demonstrated silica as a main mineral component in that lesion, which was suspected as a cause of the patient’s anthracofibrosis.

KEYWORDS

Silicosis 

Received 18 Aug 2020 / Accepted 30 Oct 2020

AJRS, 10(2): 187-190, 2021

Google Scholar