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日本呼吸器学会英文誌 Respiratory Investigation
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Abstract

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Article in Japanese

Case Report

A case of granulomatosis with polyangiitis coinciding with asbestosis

Ken Shirahasea  Osamu Nishiyamaa  Takashi Oomoria  Sho Saekia  Shigeki Shimizub  Yuji Tohdaa 

aDepartment of Respiratory Medicine and Allergology, Kindai University, Faculty of Medicine
bDepartment of Pathology, Kinki Central Hospital of the Mutual Aid Association of Public School Teachers

ABSTRACT

An 84-year-old man with asbestosis presented with newly developed infiltrates in bilateral lower lobes that were superimposed on existing shadows of asbestosis on his chest computed tomography (CT). Histological findings of lung specimens that were obtained from the new infiltrates with transbronchial forceps showed that neutrophil infiltration was destroying pulmonary vessels, indicating vasculitis. With myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) positivity, he was diagnosed with granulomatosis with polyangiitis (GPA). The patient is, to our knowledge, the first reported coincident case of asbestosis and GPA, indicating significant relationships among pneumoconiosis, ANCA production, and vasculitis.

KEYWORDS

Asbestosis  Granulomatosis with polyangiitis (GPA)  Interstitial lung disease  Myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) 

Received 18 Jul 2020 / Accepted 24 Nov 2020

AJRS, 10(2): 178-182, 2021

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