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日本呼吸器学会英文誌 Respiratory Investigation
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Abstract

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Article in Japanese

Original Article

Comparative performance of two pressurized metered-dose inhalers using Aerosphere® delivery technology and of the Ellipta® to administer combined triple therapy ICS/LABA/LAMA

Gen Tamuraa  Hirokazu Sakaeb  Satoshi Fujinob 

aAirway Institute in Sendai
bTokyo Dylec Corp.

ABSTRACT

We measured the particle size distribution of aerosols and the percentage of aerosolization of the Breztri® Aerosphere,® the Bevespi® Aerosphere,® and the dry-powder inhaler Trelegy® 100-Ellipta®. Although all devices showed a single peak, the mass median aerodynamic diameter of the Breztri® is 2.51 μm at 30 L/min flow rate and 2.53 μm at 60 L/min flow rate, that of the Bevespi® is 2.26 μm and 2.66 μm, and that of the Trelegy® is 3.76 μm and 3.87 μm, respectively. Percentages of aerosolization of the pressurized metered-dose inhalers are about 98% at 28.3 L/min flow rate and about 93% at 60 L/min flow rate. Those of the dry powder inhaler are about 9% and 8%, respectively.

KEYWORDS

Breztri®  Bevespi®  Trelegy®  Particle size distribution of aerosol  Percentage of aerosolization 

Received 7 Oct 2020 / Accepted 18 Nov 2020

AJRS, 10(2): 108-112, 2021

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