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日本呼吸器学会英文誌 Respiratory Investigation
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Abstract

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Article in Japanese

Case Report

Short-term treatment with systemic steroids in moderate coronavirus infectious disease 2019: a case report and review of domestic cases

Kentaro Fukunagaa  Yasuki Uchidab  Yasushi Omuraa Yuki Yagia  Daisuke Kinoseb  Masafumi Yamaguchib 

aDepartment of Internal Medicine, Kohka Public Hospital
bDivision of Respiratory Medicine, Department of Internal Medicine,Shiga University of Medical Science

ABSTRACT

Effective treatment for coronavirus infectious disease 2019 has not yet been established. Infection with severe acute respiratory syndrome coronavirus 2 induces hypercytokinemia. Consequently, patients may develop pneumonia and, in severe cases, acute respiratory distress syndrome. Therefore, it is necessary to develop a therapeutic strategy to suppress inflammatory cytokines. Two of our patients showed aggravated symptoms despite the use of antiviral drugs. Short-term treatment with systemic steroids in the moderate phase improved their condition. Similar results have been reported in other cases in Japan and other countries. It is necessary to consider short-term treatment with systemic steroids along with antiviral drugs in the event of poor response to antiviral drugs and hypoxia.

KEYWORDS

Coronavirus infectious disease 2019 (COVID-19)  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)  Viral pneumonia  Systemic steroid 

Received 2 Jun 2020 / Accepted 4 Aug 2020

AJRS, 9(6): 432-437, 2020

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