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日本呼吸器学会英文誌 Respiratory Investigation
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Abstract

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Article in Japanese

Case Report

A case of vocal cord leukoplakia caused by gastroesophageal reflux following whooping cough

Hideto Oshita  Noriaki Ito  Misato Senoo  Kunihiko Funaishi  Kohei Kawasaki  Ken Okusaki 

Department of Internal Medicine, Mihara Medical Association Hospital

ABSTRACT

A 35-year-old man developed paroxysmal cough, hoarseness, and fever. Whooping cough was strongly suspected because of high serum anti-pertussis toxin antibody titers. Although the patient was administered macrolide antibiotics, paroxysmal cough with prolonged vomiting ensued and was eventually complicated with pneumonia due to microaspiration. Bronchoscopic examination revealed leukoplakia and atrophy in the left vocal cord and glottic closure impairment. We hypothesized that the vocal cord lesions were caused by a cough-reflux self-perpetuating positive feedback cycle. Treatment for gastroesophageal reflux disease resulted in an improvement in symptoms and disappearance of the vocal cord lesions.

KEYWORDS

Whooping cough  Vocal cord leukoplakia  Gastroesophageal reflux disease (GERD)  Laryngopharyngeal reflux disease 

Received 10 May 2019 / Accepted 18 Jun 2019

AJRS, 8(5): 340-343, 2019

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