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日本呼吸器学会英文誌 Respiratory Investigation
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Abstract

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Article in Japanese

Case Report

An autopsied case of invasive pulmonary aspergillosis secondary to the severe fever with thrombocytopenia syndrome virus infection

Ryosuke Fujita  Yusuke Ajishi  Seiya Nishiyama  Tomoaki Kumabe  Tetsuro Yamaguchi 

Department of Internal Medicine, Miyazaki Prefectural Nobeoka Hospital

ABSTRACT

Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease caused by the SFTS virus. We recently encountered a patient with invasive pulmonary aspergillosis (IPA) secondary to SFTS virus infection. The patient, who had fever, leukopenia, and thrombocytopenia, was referred to our hospital for treatment. On admission, blood tests indicated a diagnosis of SFTS. Multiple pulmonary shadows appeared on an X-ray image during hospitalization but there was no response to antibacterial drugs. Aspergillus spp. was detected in the sputum. He died of sepsis and disseminated intravascular coagulation. We considered that IPA had probably developed because of severe immunodeficiency caused by the SFTS virus infection and high-dose steroid therapy.

KEYWORDS

Severe fever with thrombocytopenia syndrome (SFTS)  Immunodeficiency  Invasive pulmonary aspergillosis (IPA) 

Received 20 Nov 2018 / Accepted 5 Feb 2019

AJRS, 8(3): 178-182, 2019

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