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Abstract

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Article in Japanese

Case Report

A case of lung cancer in a patient with indium lung disease

Atsuko Amataa  Tatsuya Chonana  Yuuki Yabuuchia  Hideo Ichimurab  Takeshi Nawac  Yoshinori Kawabatad 

aDepartment of Internal Medicine, Nikko Memorial Hospital
bDepartment of Thoracic Surgery, Hitachi Medical Education and Research Center, University of Tsukuba
cDepartment of Respiratory Medicine, Hitachi General Hospital
dDepartment of Pathology, Saitama Cardiovascular and Respiratory Center

ABSTRACT

The production of indium compounds to manufacture liquid crystal displays has recently increased. This is concerning because inhaled indium can cause pulmonary toxicities like interstitial pneumonia and emphysema. Carcinogenesis associated with indium exposure has been demonstrated in animal experiments; however, limited reports exist for humans. Here, we present a case of lung cancer that developed in a 46-year-old man diagnosed with interstitial pneumonia owing to indium lung disease 16 years ago after occupational exposure to indium-tin oxide for 12 years. The patient also had a history of interstitial pneumonia exacerbation 6 years ago. He visited our hospital with complaints of left-sided chest discomfort. Chest X-ray revealed a mass shadow in his left-sided upper lung with left-sided pleural effusion. He was subsequently diagnosed with lung adenocarcinoma with pleural dissemination following video-assisted thoracic surgery and pathological examination. Moreover, pulmonary fibrosis and cholesterol granulomas were noted, consistent with indium lung disease. Although serum KL-6 and indium levels decreased slowly, they remained at 1,460U/mL and 9.97ng/mL, respectively. Since exposure to high indium levels can induce lung cancer, we need to be aware of the complication of lung cancer, particularly in individuals with interstitial pneumonia.

KEYWORDS

Indium-tin oxide (ITO)  Lung adenocarcinoma  Interstitial pneumonia  Occupational lung cancer 

Received 18 Oct 2018 / Accepted 12 Feb 2019

AJRS, 8(3): 158-162, 2019

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