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Article in Japanese
Abstract
Case Report
A suspected case of drug-induced pneumonia due to atorvastatin and/or montelukast
Hideo Yadaa Toyomitsu Sawaia Satoru Kogaa Sumako Yoshiokaa Nobuko Matsuoa Hiroshi Mukaeb
aDepartment of Respiratory Medicine, Nagasaki Harbor Medical Center
bSecond Department of Internal Medicine, Nagasaki University Hospital
ABSTRACT
A 76-year-old female nonsmoker presented to our hospital with an abnormal chest radiograph. She had been taking atorvastatin for 2 years and montelukast for 6 months. Chest radiograph showed infiltrates in both middle lung fields. Flexible fiberscopic bronchoscopy was performed on hospital day 8. The bronchoalveolar lavage fluid lymphocyte count was elevated, and transbronchial lung biopsy specimen showed organizing pneumonia on histological examination. Treatment with methylprednisolone 500mg intravenously every 24 hours was initiated. After 3 days of this treatment, chest radiographs showed a gradual improvement, and the methylprednisolone dosage was lowered. The drug-induced lymphocyte stimulation tests for montelukast and atorvastatin were positive. Based on these findings, drug-induced pneumonitis was suspected.
KEYWORDS
Drug-induced pneumonia Montelukast Atorvastatin
Received 18 Jan 2018 ／ Accepted 11 Sep 2018
AJRS, 8(1): 36-41, 2019
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