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Abstract

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Article in Japanese

Case Report

A case of lung adenocarcinoma with long-term anti-tumor maintenance after the discontinuation of nivolumab due to polymyalgia rheumatica

Tsunetaka Murayamaa  Kentaro Fukunagaa  Yoko Hirayamab  Tomoko Iriyamaa  Yuto Katoa  Yasutaka Nakanoa 

aDivision of Respiratory Medicine, Department of Internal Medicine, Shiga University of Medical Science
bDepartment of Pulmonary Medicine, Nagahama City Hospital

ABSTRACT

A 71-year-old man was diagnosed as having a Stage IV (cT1aN0M1b) lung adenocarcinoma 4 years previously. The patient developed stiffness in both shoulders, fatigue, and low-grade fever after 12 courses of nivolumab. After detailed examination, he was diagnosed with polymyalgia rheumatica (PMR) precipitated by an immune-related adverse event. Nivolumab was discontinued, and oral prednisolone was started for the treatment of PMR. The patient attained remission with oral prednisolone. He maintained a partial response for about 1 year after the cessation of treatment for the lung adenocarcinoma. This case suggests that the development of PMR precipitated by nivolumab treatment may be associated with a good prognosis in non-small cell lung cancer.

KEYWORDS

Lung adenocarcinoma  Nivolumab  Immune-related adverse events (irAE)  Polymyalgia rheumatica (PMR) 

Received 4 Mar 2018 / Accepted 22 Aug 2018

AJRS, 7(6): 394-398, 2018

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