Full Text of PDF (682k)
Article in Japanese
Abstract
Case Report
A case of necrotizing diverticulitis of colon associated with nintedanib
Yumiko Mitaa Kazuyuki Nishimurab Atsushi Miurab Tomohito Nagaib Jun Tamaokia
aFirst Department of Medicine, Tokyo Women's Medical University Hospital
bDepartment of Respiratory Medicine, Saitama Saiseikai Kurihashi Hospital
ABSTRACT
A 69-year-old man received nintedanib treatment for idiopathic pulmonary fibrosis. After nintedanib treatment was initiated, he had acute abdomen resulting in an emergency right hemicolectomy. He was diagnosed with necrotizing diverticulitis of colon based on pathologic examination of the resected tissue. Intracellular signal transduction inhibitors including nintedanib are known to be associated with such adverse events as hemorrhage, thrombosis, and protracted wound healing. In particular, gastrointestinal (GI) perforation has been frequently reported with bevacizumab, a vascular endothelial growth factor (VEGF) inhibitor. Pretreatment assessment for the patient’s susceptibility to GI adverse effects may be warranted before administration of nintedanib, an inhibitor of the VEGF receptor. We here report a case that developed necrotizing diverticulitis of colon attributed to nintedanib treatment.
KEYWORDS
Nintedanib Idiopathic pulmonary fibrosis (IPF) Necrotizing diverticulitis of colon
Received 20 Nov 2017 ／ Accepted 16 Apr 2018
AJRS, 7(4): 263-266, 2018
Copyright © The Japanese Respiratory Society All Rights Reserved.