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日本呼吸器学会英文誌 Respiratory Investigation
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Abstract

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Article in Japanese

Case Report

A case of interstitial pneumonia with antisynthetase (anti-PL-7 antibody) syndrome that manifested after lung cancer surgery

Tsugitoshi Onukia  Naoko Matoa  Yu Yasudab  Shinichi Yamamotoc  Masashi Bandoa  Koichi Hagiwaraa 

aDivision of Pulmonary Medicine, Department of Medicine, Jichi Medical University
bDivision of Cardiovascular Disease, Shimane Prefectural Central Hospital
cDivision of Pulmonary Medicine, Department of General Thoracic Surgery, Jichi Medical University

ABSTRACT

A 64-year-old man received thoracoscopic lung resection for primary lung adenocarcinoma in the left upper lobe. After the surgery, cough and skin rash with desquamation appeared. chest computed tomography (CT) exhibited new interstitial opacities with traction bronchiectasis in the lower lobes. Serum tested positive for anti-PL-7 antibodies. We made a diagnosis of interstitial pneumonia associated with anti-aminoacyl-tRNA synthetase antibody (ARS) syndrome. Examination of excised lung confirmed the existence of pathological changes suggestive of interstitial pneumonia, indicating that the syndrome was already present at the time of surgery. We speculated that pre-existing interstitial pneumonia with anti-ARS antibody syndrome became clinically apparent through the stress of surgery. He was treated with glucocorticoids and his symptoms gradually improved. We report a case of interstitial pneumonia associated with anti-ARS antibody syndrome, that became clinically apparent after lung cancer surgery.

KEYWORDS

Antisynthetase syndrome  Anti-PL-7 antibody  Interstitial pneumonia  Lung cancer 

Received 10 Dec 2017 / Accepted 6 Mar 2018

AJRS, 7(3): 192-196, 2018

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