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Abstract

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Article in Japanese

Case Report

A case of Good syndrome accompanied by a macrolide-resistant diffuse panbronchiolitis-like symptoms

Masamitsu Shimizu  Yoshinobu Saito  Yukiko Miura  Yuji Minegishi  Arata Azuma  Akihiko Gemma 

Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School

ABSTRACT

The patient was a 50-year-old woman diagnosed with myasthenia gravis and thymoma who was being treated with radiochemotherapy, steroid administration, and immunosuppressive therapy after thymectomy. Approximately 5 years after the diagnosis, productive cough developed and centrilobular granular shadows in both lung fields were observed by chest contrast-enhanced computed tomography (CT). Diffuse panbronchiolitis (DPB) was ruled out by a negative HLA-B54 gene test result. Her condition was associated with hypogammaglobulinemia due to a decreased B-cell count.
Good syndrome complicated by DPB-like symptoms was diagnosed. We report this case because macrolide-resistant cases, such as that of our current patient, are rare.

KEYWORDS

Good syndrome  Hypogammaglobulinemia  Diffuse panbronchiolitis  HLA-B54 gene  Macrolide therapy 

Received 27 Jul 2017 / Accepted 13 Feb 2018

AJRS, 7(3): 171-176, 2018

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