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Abstract

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Article in Japanese

Case Report

A case of spontaneous regression of small cell lung cancer with anti-Hu-antibody-positive paraneoplastic neurological syndrome

Yusuke Hamakawa  Shinichiro Ota  Maiko Awashima  Yuji Fujikura  Soichiro Kanoh  Akihiko Kawana 

Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College

ABSTRACT

A 76-year-old man presented with depression, irritation, fatigue, and nausea. Unenhanced computed tomography of the chest revealed a nodule in the right lower lobe, with right mediastinal and hilar lymph node enlargement. The patient was referred to our hospital for further examination.
When the patient was admitted to our hospital, the nodule showed spontaneous regression. Small cell carcinoma cells were detected on endobronchial ultrasound-guided transbronchial needle aspiration.
During hospitalization, the patient developed acute cerebellar ataxia and disorientation. He tested positive for the anti-Hu antibody. Clinical and laboratory findings led to a diagnosis of paraneoplastic neurologic syndrome.
Spontaneous regression is thought to be caused by autoimmune processes triggered by anti-neuronal autoantibodies.

KEYWORDS

Small cell lung cancer  Paraneoplastic neurologic syndrome  Anti-Hu antibody  Spontaneous regression 

Received 8 Dec 2017 / Accepted 15 Feb 2018

AJRS, 7(3): 146-150, 2018

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