Full Text of PDF (365k)
Article in Japanese
Abstract
Case Report
A case of anti-OJ antibody positive ILD presenting with acute respiratory failure
Reina Sekiyaa,* Chihiro Nishiob Hiromi Tomiokaa Shuji Yamashitaa
aDepartment of Respiratory Medicine, Kobe City Medical Center West Hospital
bDepartment of General Medicine, Kobe City Medical Center West Hospital
*Present address: Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
ABSTRACT
A 42-year-old woman was admitted to our hospital because of cough and sputum. She had no muscle weakness, but she did have heliotrope rash. A chest high-resolution plain CT showed patchy air-space consolidation with ground-glass opacity indicating interstitial pneumonia. The diagnosis of clinically amyopathic dermatomyositis was made. She had a favorable response to the treatments of pulsed methylprednisolone, pulsed cyclophosphamide, and tacrolimus therapy. However, areas of ground-glass opacity increased during a gradual taper of prednisone. Although a MESACUPTM anti-ARS test was negative for antiaminoacyl-tRNA synthetase antibodies, the patient was found to be positive for anti-OJ-antibody by RNA immunoprecipitation assay.
KEYWORDS
Anti-synthetase syndrome Anti-OJ (anti-isoleucyl-tRNA synthetase) antibody Interstitial pneumonia Clinically amyopathic dermatomyositis
Received 20 Jun 2016 ／ Accepted 13 Dec 2016
AJRS, 6(4): 235-239, 2017
Copyright © The Japanese Respiratory Society All Rights Reserved.