一般社団法人日本呼吸器学会 公式サイト
日本呼吸器学会英文誌 Respiratory Investigation
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集 検索用
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集 全文PDF

Abstract

Full Text of PDF Full Text of PDF (406k)
Article in Japanese

Case Report

A case of drug-induced pneumonitis by dietary supplement containing Agaricus during clinical course of squamous cell lung cancer

Hiroaki Muranoa  Sumito Inoueb  Yoshikane Tokairinb  Akira Igarashib  Yoko Shibatab  Isao Kubotab 

aPostgraduate Clinical Training Center, Yamagata University Hospital
bDepartment of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

ABSTRACT

A 70-year-old man had for two months taken a dietary supplement containing Agaricus as followup after an operation for lung cancer. He was admitted to the hospital because of fever. Although he was diagnosed as pneumonia and treated by antibiotic, his symptoms did not improve. A chest CT scan revealed ground-glass attenuations with some small patchy consolidations in the left lung, and increasing total cell counts and lymphocytes in bronchoalveolar lavage fluid were observed. Because the results of a drug lymphocyte stimulation test against Agaricus were positive, we diagnosed him as drug-induced pneumonitis associated with Agaricus. He was treated with oral corticosteroid, and his symptoms and lung abnormalities improved. To our knowledge, few cases of lung injury induced by Agaricus have been reported. We need to consider that many patients with cancer take dietary supplements.

KEYWORDS

Lung cancer  Drug-induced lung injury  Agaricus blazei Murill  Dietary supplement 

Received 14 Mar 2016 / Accepted 26 Dec 2016

AJRS, 6(3): 186-189, 2017

Google Scholar