A 61-year-old male was referred to our hospital for treatment of acute myelocytic leukemia. After the induction therapy, he had high fever and hemoptysis. A chest CT scan revealed severe bilateral pneumonia. He was treated with broader-spectrum antibiotic and antifungal agents. On the basis of his clinical course, he was diagnosed as fungal pneumonia, especially pulmonary zygomycosis. He continued to receive only antifungal agents, such as liposomal amphotericin B and caspofungin. Although his clinical and laboratory findings had been improved, abnormal lung shadows still remained. Because of the recurrence of hemoptysis, we decided to resect those shadows to control hemoptysis. First, a left upper lobectomy was performed 118 days after admission. Second, partial resection of the right upper lobe was performed on 168 days. The final pathological diagnosis was pulmonary zygomycosis. After two-stage resection, he continued to receive chemotherapy without recurrence of pulmonary zygomycosis. We were able to successfully treat pulmonary zygomycosis in combination with surgery and sandwich (pre- and postoperative) chemotherapy.