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Article in Japanese
Abstract
Case Report
A case of methotrexate-associated lymphoproliferative disorder presenting with methotrexate therapy for a long term
Mamiko Suzuki Fumio Kumasawa Tetsuo Shimizu Daisuke Endo Yasuhiro Gon Noriaki Takahashi Shu Hashimoto
Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine
ABSTRACT
A 70-year-old male had diagnosed rheumatoid arthritis, and methotrexate (MTX) therapy was started in 2003. The combination therapies of MTX and adalimumab were started in 2006. He had revealed symptoms of pyrexia and dry cough in June 2013. In July, a chest X-ray showed a tumor in the right lung field; therefore he was admitted to our hospital. His symptoms and the radiographic findings were not improved by stopping the adalimumab therapy. We demonstrated endobronchial ultrasound-guided transbronchial needle aspiration, the pathological findings were observed, proliferation of atypical lymphocytes, and the Epstein-Barr virus infection. We diagnosed methotrexate-associated lymphoproliferative disorder with a term of 10 years from MTX therapy. His symptoms and radiographic findings were improved after discontinuation of the MTX therapy.
KEYWORDS
Methotrexate Methotrexate-associated lymphoproliferative disorder Malignant lymphoma Epstein-Barr virus
Received 25 Aug 2014 ／ Accepted 18 Nov 2014
AJRS, 4(2): 158-161, 2015
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