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Abstract

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Article in Japanese

Case Report

A successful salvage operation for stage IV non-small cell lung cancer after effective chemotherapy

Hideya Iijimaa  Ryo Horaguchia  Yumika Sekia  Yuji Sudaa  Yuriko Shindoha  Takashi Sawaib 

aDepartment of Respiratory Medicine, Sendai Open Hospital
bDepartment of Pathology, Sendai Open Hospital

ABSTRACT

A-66-year-old male was referred to our hospital for Stage IV (cT4N3M1a) adenocarcinoma of the right middle lobe. Although the chemotherapy with carboplatin, pemetrexed, and bevacizumab was effective, it was finished in 3 courses because of poor tolerability, and he underwent a partial resection of the right middle and lower lobes and the diaphragm. More than 90% of the primary lesion showed fibrosis and remaining cancer cells, some of which expressed Ki67, that were surrounded by abundant lymphocytes. All of the other resected metastatic lesions showed fibrosis with no survival of cancer cells. Followed by two courses of adjuvant chemotherapy, he is now under observation in the state of PS-0 without recurrence for 9 months. Before 2nd line chemotherapy, salvage surgery may also need to be taken into consideration as one means of the multimodal therapy for stage IV non-small cell lung cancer if the case is chosen appropriately.

KEYWORDS

Non-small cell lung cancer  Salvage surgery  Cytotoxic T lymphocyte 

Received 23 Aug 2014 / Accepted 31 Oct 2014

AJRS, 4(2): 144-148, 2015

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