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Abstract

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Article in Japanese

Original Article

Clinical analysis of pulmonary nocardiosis: A retrospective, single center study

Takashi Ishiguroa  Noboru Takayanagia  Tohru Gonoib  Masaki Tamuraa  Yotaro Takakua  Naho Kagiyamaa  Akira Watanabeb  Katsuhiko Kameib  Yutaka Sugitaa 

aDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center
bMedical Mycology Research Center, Chiba University

ABSTRACT

Reports reviewing clinical characteristics of pulmonary nocardiosis are limited. Twelve cases of pulmonary nocardiosis presenting from 2000 to 2013 were retrospectively analyzed. The patients were 69.0±12.4 years of age, and 10 were men. Eight patients developed mixed infections throughout their courses, respectively. Sulfamethoxazole-trimethoprim was administered in 9 patients as the initial antibiotics; however, this combination was not tolerated by 5 patients and required exchange of antibiotics. Six patients died during the follow-up period, but causes of death did not include pulmonary nocardiosis. In conclusion, mixed infection was not rare in patients with pulmonary nocardiosis. Careful attention should be paid to such patients because the frequency of side effects from sulfamethoxazole-trimethoprim is not low, and the effects of underlying diseases on prognosis should not be ignored.

KEYWORDS

Nocardia  Pulmonary nocardiosis  16S rRNA 

Received 18 Aug 2014 / Accepted 3 Nov 2014

AJRS, 4(2): 133-138, 2015

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