一般社団法人日本呼吸器学会 公式サイト
日本呼吸器学会英文誌 Respiratory Investigation
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集

Abstract

Full Text of PDF Full Text of PDF (513k)
Article in Japanese

Topics Series Structure and function

Adipokines and myokines as biomarkers for COPD?

Yoko Shibata 

Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

ABSTRACT

In patients with chronic obstructive pulmonary disease (COPD), various alterations of body composition are observed. Not only is cachexia frequently comorbid with COPD patients, but metabolic syndrome is also. The physical activity of COPD patients is important for their healthy status, and is associated with a mass of visceral fat and skeletal muscle. Although adiponectin, released from fat tissue, is known as cardioprotective and an anti-atherosclerotic factor, its levels in COPD patients were reportedly higher than in control subjects. Moreover, higher adiponectin levels were associated with higher mortality as a result of respiratory diseases. IL-6, a typical myokine produced from exercising skeletal muscles, has various effects, such as regeneration, growth, and proliferation of skeletal muscles. However, precise roles of muscle-derived IL-6 in exercising COPD patients have not been fully investigated.

KEYWORDS

COPD  Adiponectin  IL-6  Metabolic syndrome 

AJRS, 4(1): 23-28, 2015

Google Scholar