An 80-year-old woman was admitted to our hospital because of dyspnea and fever. She had been taken Calonal^®, which includes acetaminophen as the active ingredient. Increased eosinophils in bronchoalveolar lavage fluid suggested that she had an eosinophilic pneumonia (EP). Her pulmonary involvement resolved after discontinuation of acetaminophen and administration of corticosteroid. Six months later, she visited our hospital again because of dyspnea. She had been taking Coughcode^®-N, a combination cold remedy that contains acetaminophen, before the arrival. The patient's history, increased eosinophils in the peripheral blood, and the radiologic findings were consistent with a relapse of drug-induced EP caused by acetaminophen. Pulmonary involvements improved immediately after discontinuation of acetaminophen and the administration of corticosteroid. This valuable case diagnosed by readministration of acetaminophen as a combination remedy underlines that acetaminophen can induce EP and that we must pay special attention when prescribing combination products.