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Abstract
Case Report
An autopsy case of pleural mesothelioma that presented rapid progression and multiple organ metastasis after disease control for 5 years
Shinichiro Otaa,b Yu Haraa,c Masaharu Shinkaia,c Keisuke Watanabea Yoshiaki Inayamad Takeshi Kanekoe
aRespiratory Disease Center, Yokohama City University Medical Center
bDepartment of Internal Medicine, Japan Self-Defense Force Hospital Yokosuka
cDivision of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College
dDepartment of Pathology, Yokohama City University Medical Center
eDepartment of Pulmonology, Yokohama City University Graduate School of Medicine
ABSTRACT
A 52-year-old man had been hospitalized in April 2006 as a result of right chest pain. Chest computed tomography had shown right pleural effusion and pleural thickening, and open pleural biopsy specimens had revealed as epithelioid-type pleural mesothelioma (PM). Chemotherapy had been performed, and we could control the disease progression for 5 years. However, in June 2011 the remarkable increase of pleural effusion and brain metastasis appeared. He died after five months despite treatment, and by autopsy we found the expansion of the primary lesion and extensive metastatic lesions (brain, peritoneum, pancreas, liver, spleen, and bone). Histological findings of brain and pleural lesions were sarcomatoid-type predominant PM. Considering a pathogenesis of PM, this is an interesting case, because intermingled sarcomatous components or epithelial mesenchymal transition might influence the disease progression.
KEYWORDS
Pleural mesothelioma Pemetrexed Long-term survivor Multiple organ metastasis
Received 9 Sep 2013 ／ Accepted 22 Jul 2014
AJRS, 3(6): 800-804, 2014
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