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Abstract

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Article in Japanese

Topics Series Cell and molecular biology

Costimulatory and coinhibitory molecules in immunoregulation and immunotherapy

Naoto Ishii 

Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine

ABSTRACT

Optimal T cell responses require costimulatory and coinhibitory signals. T cell costimulatory signals are essential for T cell activation, and T cell coinhibitory signals control and finely tune the T cell responses. Here I review the role of T cell costimulatory and coinhibitory molecules, and discuss possible therapeutic strategies targeting these molecules.

KEYWORDS

Costimulatory molecule  Coinhibitory molecule  T cell  Immunotherapy 

AJRS, 3(5): 643-649, 2014

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