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Abstract

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Article in Japanese

Topics Series Pulmonary circulation and lung injury

Vascular response of pulmonary circulation

Yoshiteru Morioa  Yasushi Hoshikawab 

aDivision of Respiratory Medicine, Juntendo University School of Medicine
bDepartment of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University

ABSTRACT

Pulmonary circulation has peculiar characteristics. They demonstrate a remarkable alteration from fetal circulation at birth and also vasoconstriction under hypoxic exposure that are quite different from systemic circulation. The mechanism of hypoxic pulmonary vasoconstriction reveals multiple pathogenesis, although it remains to be elucidated. Each of the vascular mediators of three major pathways, such as prostacyclin-, endothelin-, and nitric-oxide-dependent pathways that correspond to current therapeutic targets for pulmonary arterial hypertension, causes various effects on pulmonary circulation. This article reviews the specific vascular responses of pulmonary circulation.

KEYWORDS

Hypoxic pulmonary vasoconstriction  Nitric oxide  Prostacyclin  Endothelin 

AJRS, 3(4): 464-470, 2014

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