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Abstract

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Article in Japanese

Case Report

A case of lung cancer complicated by idiopathic central diabetes insipidus in which diagnosis and treatment for polyuria were difficult

Yuko Asatoa,*  Sumire Ootanib  Mizuki Kuramochic  Mitsuhide Narused 

aDepartment of Respiratory Medicine, National Hospital Organization Saitama National Hospital
bDepartment of Internal Medicine, National Hospital Organization Saitama National Hospital
cDepartment of Gastrointestinal Medicine, National Hospital Organization Saitama National Hospital
dDepartment of Endocrinology, Metabolism, and Hypertension, National Hospital Organization Kyoto Medical Center
*Present address: Department of Internal Medicine, Respiratory Division, Tokyo Metropolitan Police Hospital

ABSTRACT

We report the case of a 44-year-old male patient with lung cancer complicated by idiopathic central diabetes insipidus without brain metastasis. The patient had suffered from polydipsia and polyuria from a young age. Examination of the patient revealed associated dilatation of the lower urinary tract and hypercalcemia. The cause of polydipsia and polyuria was considered to be central diabetes insipidus, and the patient exhibited a complex pathology because of hypercalcemia, a paraneoplastic syndrome, and hydronephrosis caused by polyuria. Treatment of central diabetes insipidus, normalization of calcium levels, and placement of a urethral catheter for urinary tract dilatation allowed standard platinum-containing chemotherapy to be administered for lung cancer. We report this case, in which the patient presented with a very rare pathological condition.

KEYWORDS

Non-small cell lung cancer  Central diabetes insipidus  Hydronephrosis  Hypercalcemia 

Received 25 Apr 2013 / Accepted 16 Dec 2013

AJRS, 3(3): 385-389, 2014

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