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Abstract

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Article in Japanese

Case Report

A case of Waldenström macroglobulinemia with lung tumors, interstitial infiltrations, and hypercalcemia

Hiromi Yamane  Kosuke Kashiwabara  Hideyuki Tanaka 

Department of Respiratory Medicine, National Hospital Organization Kumamoto Medical Center

ABSTRACT

An 83-year-old man was admitted to our hospital because of visual loss, photophobia, and dyspnea on exertion. Monoclonal gammopathy (IgM-λ type) was detected in the serum and lymphoplasmacytic cells proliferated in the bone marrow. Chest CT scan showed tumor shadows in the right middle and lower lobes and interstitial shadows in both lung fields. These shadows were diagnosed as pulmonary involvements of Waldenström macroglobulinemia because transbronchial lung biopsy specimen showed IgM-λ-positive lymphoplasmacytic cells infiltrated in both tumor and lung interstitium. This patient developed blood hyperviscosity and hypercalcemia refractory to therapy.

KEYWORDS

Macroglobulinemia  TBLB  Hyperviscosity syndrome  Hypercalcemia 

Received 6 Jun 2013 / Accepted 26 Aug 2013

AJRS, 3(1): 111-115, 2014

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