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Abstract

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Article in Japanese

Case Report

A case of tumor lysis syndrome successfully treated by rasburicase during chemotherapy for large-cell neuroendocrine carcinoma of the lung

Yohei Suzuki  Tadashi Sato  Haruhi Takagi  Yuichi Fujimoto  Shinsaku Togo  Kazuhisa Takahashi 

Department of Respiratory Medicine, Juntendo University Graduate School of Medicine

ABSTRACT

We report a rare case of large-cell neuroendocrine lung carcinoma exhibiting tumor lysis syndrome (TLS) while receiving chemotherapy and being successfully treated by rasburicase. A 70-year-old man was diagnosed with large-cell neuroendocrine carcinoma after being operated on for a left upper lung carcinoma. He had received adjuvant chemotherapy after the operation, but it resulted in a metastatic liver tumor. Five days after administration of amrubicin as the second-line chemotherapy, TLS occurred with an elevation of uric acid, potassium, and creatinine in serum. To elude the severe renal dysfunction, rasburicase was used in addition to the usual fluid therapy. The value of uric acid was remarkably decreased, and the renal function was improved after 3 days of rasburicase administration. Rasburicase thus might be useful for the initial treatment of TLS even in the clinical course of lung cancer.

KEYWORDS

Large-cell neuroendocrine carcinoma (LCNEC)  Uric acid  Tumor lysis syndrome  Rasburicase  Alloprinol 

Received 12 Feb 2013 / Accepted 16 Jul 2013

AJRS, 2(6): 746-750, 2013

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