一般社団法人日本呼吸器学会 公式サイト
日本呼吸器学会英文誌 Respiratory Investigation
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集

Abstract

Full Text of PDF Full Text of PDF (689k)
Article in Japanese

Original Article

Transverse myelopathy: An initial symptom of metastasis of primary lung cancer to the spine

Yuhei Tokimasaa  Kiyoshi Matsuoa,*  Gou Makimotoa  Hisao Higoa  Nobuhisa Kameyamaa  Mizuho Matsushitaa  Ken Satoa  Keiichi Fujiwaraa  Toshiro Yoneia  Toshio Satoa 

aDepartment of Respiratory Medicine, National Hospital Organization Okayama Medical Center
*Present address: Tsuda Clinic

ABSTRACT

Transverse myelopathy resulting from metastasis of primary lung cancer to the spine causes pain, numbness, muscle weakness, extremity palsy, and bladder and rectal disturbances. This reduces the quality of life (QOL) and performance status (PS) of patients. Further, it is often difficult to perform surgery on the spinal cord and to administer chemotherapy and radiotherapy. We experienced 13 cases (10 men; 3 women; mean age, 64 years) of transverse myelopathy, an initial symptom of metastasis of primary lung cancer to the spine, from April 2004 to March 2012. Histologically, 10 cases were identified as adenocarcinoma; 2 as squamous cell carcinoma; and 1, as small-cell carcinoma. Direct decompressive surgery was performed in 8 cases, and the neurological symptoms improved in 6. Ten cases were treated with chemotherapy and 8 with radiotherapy. The median survival time was 232 days (6-428), and 3 patients survived for more than 1 year. The findings suggest that the prognosis in cases of transverse myelopathy is poor; however, adequate therapy, including surgery, might improve the neurological symptoms, QOL, PS, and prognosis.

KEYWORDS

Lung cancer  Transverse myelopathy  Spine metastasis  Bone metastasis  Tokuhashi score 

Received 27 Jul 2012 / Accepted 22 Mar 2013

AJRS, 2(4): 321-326, 2013

Google Scholar