一般社団法人日本呼吸器学会 公式サイト
日本呼吸器学会英文誌 Respiratory Investigation
日本呼吸器学会誌 増刊号 学術講演会プログラム 抄録集

Abstract

Full Text of PDF Full Text of PDF (753k)
Article in Japanese

Original Article

Radiation-induced lung injury outside the irradiated area after radiation therapy for breast cancer

Yuki Yamamotoa,*  Kengo Murataa  Kentaro Sakashitaa,#  Maki Miyamotoa  Akihiko Wadaa  Tetsuya Kashiyamab  Akira Fujitaa,†  Mikio Takamoria 

aDepartment of Respiratory Medicine, Tokyo Metropolitan Tama Medical Center
bDepartment of Emergency Medicine, Tokyo Metropolitan Tama Medical Center
*Present address: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
#Present address: Department of Infectious Disease, Nagasaki University School of Medicine
Present address: Tama-Hokubu Medical Center

ABSTRACT

Organizing pneumonia (OP) and eosinophilic pneumonia (EP) are known as lung injuries after radiation therapy for breast cancer. In this study, we reported nine cases of OP and a case of EP after radiation therapy. All 10 women (62±10 years of age) were nonsmokers. Nine patients received endocrine therapy after radiation therapy. The mean intervals from completion of radiation therapy to occurrence of any symptoms were 119 days. All the patients have symptoms, but none are severe. Seven patients were treated with corticosteroids, and three were without treatment. All patients improved, but a relapse occurred in three (two treated with corticosteroid, one without treatment). Because of our findings and the previous studies, tobacco smoke may have played a suppressive role in the occurrence of lung injury in nonirradiated areas after radiation therapy in breast cancer patients, and endocrine therapy may have played a promotive role.

KEYWORDS

Breast cancer  Radiation  Organizing pneumonia  Eosinophilic pneumonia 

Received 25 May 2012 / Accepted 18 Sep 2012

AJRS, 2(3): 169-174, 2013

Google Scholar