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Abstract

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Article in Japanese

Case Report

A case of primary pulmonary artery angiosarcoma associated with severe secondary pulmonary hypertension diagnosed by 18F-fluorodeoxy glucose positron emission tomography

Kenichiro Komiyamaa,b  Shohei Minezakia,b  Takaya Ichimurac  Yoshihiko Shimizuc  Minoru Kanazawaa  Kunihiko Kobayashib 

aDepartment of Respiratory Medicine, Saitama Medical University
bDepartment of Respiratory Medicine, Saitama Medical University International Medical Center
cDepartment of Pathology, Saitama Medical University International Medical Center

ABSTRACT

Primary pulmonary artery angiosarcoma is very rare. We present a case of primary pulmonary artery angiosarcoma that was diagnosed as pulmonary hypertension and subacute worsening right-sided heart failure in a 59-year-old woman. Constrast-enhanced helical CT showed large mural defects in both main pulmonary arteries, clearly delineated by contrast medium. The 18F-fluorodeoxy glucose positron emission tomography findings of pulmonary artery angiosarcoma were differentiated from those of pulmonary thromboembolism. This tumor was diagnosed at autopsy. Histopathologically, the excised tissue revealed a highly cellular growth of atypical spindle cells with immunohistological findings: positivity for factor VIII-related antigen, CD31, CD34, and UEA-1. Although the incidence of primary pulmonary artery angiosarcoma is very low, our case demonstrates that this disease entity should be included in the differential diagnosis of pulmonary thromboembolism. Patients with early FDG-PET can have curative potential with aggressive surgical intervention.

KEYWORDS

Primary pulmonary artery angiosarcoma  Secondary pulmonary hypertension  18F-Fluorodeoxy glucose positron emission tomography (FDG-PET) 

Received 25 May 2012 / Accepted 1 Aug 2012

AJRS, 2(2): 143-147, 2013

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