The objective of this study includes the epidemiological survey of airflow limitation among participants with high risks for COPD evaluated by questionnaire at the Togane lung-cancer mass screening. A total of 7,067 residents of Togane City, including 2,720 males and 4,347 females, were used for this study. Age brackets included 773, 1,128, 2,514, and 2,652 people in their 40s, 50s, 60s, and 70s, respectively. Present and past smokers with chronic respiratory symptoms or during treatment of lifestyle-related disease were included as high risks for COPD, and spirometry testing was performed. Nonsmokers suffering from passive smoking were also included as high-risk subjects for COPD. A total of 1,500 participants (926 males and 574 females) were selected by questionnaire as high risks for COPD. Spirometry testing showed 171 forced-expiratory volume in 1 second/forced vital capacity (FEV1/FVC) less than 70% (11.4%), including males 135 (14.5%) and females 36 (6.4%). The rates of FEV1/FVC less than 70% in high-risk subjects with chronic respiratory symptoms, with lifestyle-related diseases, and with both were 10.8%, 11.2%, and 14.8%, respectively, and there was no significant difference between these 3 groups. Twenty-seven (7.2%) were diagnosed as FEV1/FVC less than 70% among 376 high-risk subjects of nonsmokers suffering from passive smoking. In conclusion, this study indicated the importance of a questionnaire and spirometry for detecting subjects with airflow limitations who are suspected as having COPD. This is the first epidemiological survey for airflow limitation, among high risks according to smoking status, and for chronic respiratory symptoms or lifestyle-related disease by mass-screening.