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日本呼吸器学会英文誌 Respiratory Investigation
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Abstract

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Article in Japanese

Case Report

Drug-induced pneumonia possibly associated with temsirolimus

Hisako Kushima  Hiroshi Ishii  Atsushi Yokoyama  Satoshi Toba  Issei Tokimatsu  Jun-ichi Kadota 

Internal Medicine 2, Oita University Faculty of Medicine

ABSTRACT

A 55-year-old male with a 9-year treatment history of advanced renal cell carcinoma was treated for metastatic mediastinal lymphadenopathy with temsirolimus, a specific inhibitor of the mammalian target of rapamycin (mTOR). A month after the initiation of temsirolimus administration (25 mg/week), the patient started to reveal pyrexia, malaise, and dyspnea. A chest computed tomography taken after an additional month showed interstitial pneumonia. Laboratory tests showed an inflammatory reaction, liver dysfunction, and a high serum level of KL-6. There was lymphocytosis in the bronchoalveolar lavage fluid. This course suggested that temsirolimus caused drug-induced pneumonia, and the patient had been successfully treated with corticosteroids. In Japan, more cases of mTOR inhibitor-induced pneumonia should be collected for the proper and safe usage of temsirolimus.

KEYWORDS

Renal cell carcinoma  Temsirolimus  Drug-induced pneumonia 

Received 2 Dec 2011 / Accepted 25 Apr 2012

AJRS, 1(7): 558-561, 2012

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