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日本呼吸器学会英文誌 Respiratory Investigation
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Abstract

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Article in Japanese

Case Report

Two cases of chronic necrotizing pulmonary aspergillosis successfully treated with itraconazole oral solution

Hiroki Fukushima  Eri Hagiwara  Ryuichi Nishihira  Shigeru Komatsu  Terufumi Katou  Takashi Ogura 

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center

ABSTRACT

We here report two cases of chronic necrotizing pulmonary aspergillosis (CNPA) treated with itraconazole oral solution (ITCZ-OS). These two cases had a history of pulmonary tuberculosis and Mycobacterium kansasii infection, respectively. Bloody sputum and cough appeared after these diseases had finished, and chest computed tomography showed infiltration around the cavity with a fungus ball in it. Two cases were diagnosed as having CNPA with the symptom and CT findings in addition to biomarker and sputum culture. ITCZ-OS was chosen as a first-line therapy mainly because of economic reasons. It is less expensive and has higher AUC (area under the curve) than ITCZ capsule formulation. All symptoms were cleared after an eight-month therapy in both cases. Follow-up CT showed improvement of infiltration and fungus balls with biomarkers normalized. Minor tolerance side effects were observed during the course. This report first shows the efficacy and safety of ITCZ-OS in CNPA treatment.

KEYWORDS

Chronic necrotizing pulmonary aspergillosis  Itraconazole oral solution 

Received 22 Nov 2011 / Accepted 31 Jan 2012

AJRS, 1(5): 434-438, 2012

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