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Article in Japanese
Abstract
Case Report
A case of drug-induced lung injury caused by apalutamide
Yosuke Fukumotoa Hibiki Kandab Yuki Imazatob Kei Sasakib
aDepartment of Respiratory Medicine, University Hospital Kyoto Prefectural University of Medicine
bDepartment of Respiratory Medicine, Omi Medical Center
ABSTRACT
A 76-year-old man started treatment with apalutamide and degarelix for advanced prostate cancer. About 2 months later, the patient complained of cough and exertional dyspnea and visited our department. A computed tomography scan of the chest showed ground glass opacities with patchy distribution in both lungs. The shadows rapidly improved with suspension of both drugs and steroid pulse therapy. The drug-induced lymphocyte stimulation test (DLST) for apalutamide was found to be strongly positive, and the diagnosis of drug-induced lung injury was confirmed. We report a case of drug-induced lung injury due to apalutamide with a strong positive DLST.
KEYWORDS
Drug-induced lung injury Apalutamide Degarelix Drug-induced lymphocyte stimulation test (DLST)
Received 20 Nov 2024 ／ Accepted 27 Jan 2025
AJRS, 14(3): 147-151, 2025
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