The patient was a 77-year-old female. When she had surgery for breast cancer 6 years ago, an abnormal shadow was revealed on chest X-ray. Recently, she experienced anorexia and lower leg edema. Her chest X-ray shadow had worsened. We diagnosed her with pulmonary Mycobacterium intracellulare infection. She was prescribed antibiotics for M. intracellulare. After starting the pulmonary M. intracellulare infection treatment, she had a fever, elevated C-reactive protein levels, pleural effusion, ascites, and exacerbation of the lower leg edema. A labial salivary gland biopsy revealed that she had Sjögren’s syndrome (SS). Pathological findings from her cervical lymph node and bone marrow biopsy also suggested multicentric Castleman’s disease or TAFRO syndrome. We diagnosed her with TAFRO-like manifestations combined with SS and pulmonary M. intracellulare infection. These clinical features have been reported in some cases of SS and infectious diseases. Therefore, we concluded that these TAFRO-like manifestations were related to SS and pulmonary M. intracellulare infection.