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Article in Japanese
Abstract
Case Report
A case of Intractable asthma with a relapse of eosinophilic pneumonia after changing from mepolizumab to dupilumab
Kei Sasaki Hibiki Kanda Yuki Imazato Yosuke Fukumoto
Department of Respiratory Medicine, Omi Medical Center
ABSTRACT
This case is a 53-year-old woman who developed bronchial asthma at the age of 40 years. She presented to the hospital with cough and was diagnosed with Intractable asthma with eosinophilic pneumonia in October 20XX. We started mepolizumab every 4 weeks and obtained improvement in the asthma and pneumonia for some time. However, we changed mepolizumab to dupilumab due to poor asthma control and high fraction of exhaled nitric oxide (FeNO) and immunoglobulin E levels in August 20XX+3. Four weeks later, she presented to the hospital with fever and cough. Blood tests showed an increased eosinophil count, and chest computed tomography scan showed a pattern of bilateral patchy areas of ground-glass opacity and interlobular septal thickening. We experienced a case of severe eosinophilia and flare-up of eosinophilic pneumonia in a short period of time after switching from mepolizumab to dupilumab.
KEYWORDS
Eosinophilic pneumonia Intractable asthma Mepolizumab Dupilumab
Received 18-Oct-24 ／ Accepted 11-Dec-24
AJRS, 14(2): 82-86, 2025
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