Annals of The Japanese Respiratory Society:A suspected case of drug-induced lung injury due to a change in the composition of the COVID-19 vaccine (BNT162b2)

Vol.14 No.2 Table of Contents

Abstract

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Article in Japanese

Case Report

A suspected case of drug-induced lung injury due to a change in the composition of the COVID-19 vaccine (BNT162b2)

Hikaru Mamizu^a Maiko Mamizu^b Daisuke Ishikawa^a Hidenori Kawakami^a Toshiki Furukawa^b Takashi Ishida^a

^aDepartment of Respiratory Medicine, Niigata Prefectural Central Hospital
^bDepartment of General Medicine, Niigata Prefectural Central Hospital

ABSTRACT

A 66-year-old woman presented with persistent fever and cough after the administration of the COVID-19 vaccine (BNT162b2) that had undergone a change in composition from the previous vaccine. Chest computed tomography (CT) showed consolidation in the lower lobes of both lungs and the right upper lobe. Cell fractionation of bronchoalveolar lavage fluid showed lymphocyte proliferation. She was treated with steroids, which improved symptoms and imaging findings, but her symptoms flared up while the steroid dose was being reduced. Based on the clinical course, she was judged to have drug-induced lung injury caused by the COVID-19 vaccine. Caution should be exercised because drug-induced lung injury can occur even after multiple COVID-19 vaccinations due to changes in composition.

KEYWORDS

mRNA vaccine Coronavirus disease 2019(COVID-19) Drug-induced lung injury Tozinameran Famtozinameran

Received 28-Oct-24 ／ Accepted 11-Dec-24

AJRS, 14(2): 77-81, 2025

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