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Article in Japanese
Abstract
Case Report
A case of RET fusion mutation detected by repeated re-biopsy 3 years after the diagnosis of lung adenocarcinoma
Department of Respiratory Medicine, Kochi Health Sciences Center
ABSTRACT
A 54-year-old man with lung adenocarcinoma developed a malignant effusion during first-line chemotherapy and underwent thoracoscopic pleural biopsy under local anesthesia as the first re-biopsy, which revealed adenocarcinoma histologically. We could not search for the detection of gene mutations because of insufficient amounts of malignant cells in the collected tissue sample. Three years later, he developed a primary lesion during third-line chemotherapy and underwent transbronchial lung biopsy by using ultrathin bronchoscopy and rapid on-site cytologic evaluation as the second re-biopsy, which revealed non-small-cell carcinoma histologically. RET fusion was detected by lung cancer gene panel test. Subsequent administration of the molecular-targeted drug selpercatinib was effective for the primary lesion and multiple pleural dissemination.
KEYWORDS
Re-biopsy RET fusion Lung cancer gene panel test Ultrathin bronchoscopy
Received 25 Jun 2024 ／ Accepted 9 Aug 2024
AJRS, 13(6): 272-276, 2024
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